Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Tight Junction, Mutation Rate, Mannose
8 Apr 2018
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Document Summary
Learning objectives: the key properties of innate immunity, how barriers prevent pathogen entry into tissues, how the innate immune system recognizes and binds pathogens, extracellular versus intracellular pathogens. Innate immunity is the first line of defense against a pathogen. It is constantly ready to destroy a pathogen effective at stopping majority of pathogens at early stage. Innate immune defenses: barriers, block pathogen entry into tissues. Innate cells & proteins: rapidly eliminate pathogens that enter tissues. If innate immunity is unsuccessful: certain innate cells initiate adaptive immunity to help eliminate the pathogen. Properties of innate immunity: born with innate immune defenses, all humans the have same innate immunity, always initiated when pathogen contacts body, responds immediately to a pathogen, pathogen is usually eliminated before symptoms arise, no memory. 2: same immune response to identical pathogen with each exposure i. e. non-adaptive. Barriers: modes of pathogen entry into the body, physical barrier that prevents pathogen entry= epithelial cells.
