Pathology 3240A Lecture Notes - Lecture 2: Basic Fibroblast Growth Factor, Phagocyte, Collagen

• School: Western University
• Department: Pathology
• Course: Pathology 3240A
• Professor: Cheryl Campbell

Document Summary

Leads to loss of function of affected tissue/organ. Vascular events in inflammation: vasoconstriction, vasodilation, increased blood flow, increased permeability (which leads to swelling, hemoconcentration, cellular events. In inflammation, blood becomes viscous, causing rbcs to become crowded and stick to each other (rouleaux). The rbcs get to the middle of the bloodstream, pushing wbcs to the side. Since there is less fluid now, the wbcs get to the edge of the bloodstream. Wbcs are attracted to the endothelial cells via cams (overexpressed in inflammation), and cover the lining of the endothelium like a pavement. Wbcs are motile; through cams, wbcs roll on the surface of the endothelium and migrate out when they can. Production of chemical attractants at point of injury creates a gradient. Once the wbc gets out of the blood vessel, it knows where to go. Bacteria are coated with opsonins (usually igg or c3b).