Pathology 3240A Lecture : Class 22.docx

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Genetic determined by genes, can present itself whenever congenital abnormalities: morphological defects present at birth, may or may not be genetic bassis, 3% of newborns, most common cause of mortality in first year of life kinds of congenital abnormality, malformation intrinsic cause for abnormality in the development of limb or organ polydactyl, chd, disruption breakdown of normal development nothing intrinsically wrong with organ result from secondary destruction of an organ or body region usually extrinsic etiology ex. Amniotic band: wraps around limb, and cause auto amputation, deformation nothing intrinsically wrong extrinsic cause localized or generalized compression of growing fetus by biochemical force ex. Small uterus, large fetus oligohydramnios: decreased amount of amniotic fluid surrounding ie. club foot less cushioin exposed to compressive forces, syndrome characteristic association of several abnormalities combination of malformation and deformation for ex. Fetus: virus replicates in fetal cels, preventing proper cell division, fgrown retardation, cataracts, deafness, congenital heart, drugs/chemical disease, thalidomide.

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