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Pathology (272)
Craig Hall (18)
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Department
Pathology
Course
Pathology 3240A
Professor
Craig Hall
Semester
Winter

Description
ImmunityandImmuneDisordersAutoimmuneDiseaseandImmunodeficiencyAutoimmunityfailureofselftoleranceocentraltoleranceprogrammeddeathofselfreactiveTcellsandBcellsduringtheirmaturationinthethymusandbonemarrowrespectivelyThymicAPCspresentprocessedselfantigentoimmatureTcellsAnyTcellthatrecognizesselfantigenundergoesapoptosisDeletionBcellsrecognizingselfantigenmayundergoapoptosisorreceptoreditingChangeantigenreceptorsothatitdoesntnolongerrecognizesselfoPeripheraltoleranceinactivationordeletionofselfreactiveTcellsintheperipheralbloodtissuesieoutsidethethymusAnergyfunctionalinactivationfailuretorespondNoexpressionofcostimulatoryreceptoronlyseeingantigendoesntrespondSuppressionbyregulatoryTcellsImmunosuppressivecytokineproductionIftheyencounterintheperipheryproducecytokinesthatsuppressactivationApoptosisIfrecognizeselfantigencanundergoapoptosisTryingtoeliminateselfrecognitioninthecellFactorsinAutoimmunityoGeneticsusceptibilityFamilyassociationSpecificHLAalleleassociationGeneticpolymorphismslinkedtoAIdiseasesoInfectionsSomeinfectionsmaytriggerAIdiseasesCrossreactionofepitopeswithselfantgensTissuedamageresultsinupregulationofAPCcostimulatorymoleculesoTissueinjuryoGenderWomenmenoEnvironmentalexposuresUVradiationSmokingSLEacommonautoimmunedisorderoSystemicLupusErythrematosusMultisystemdiseaseacuteorchronicFM91
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