Pathology 3240A Lecture 5: Class 5.docx

• School: Western University
• Department: Pathology
• Course: Pathology 3240A
• Professor: Craig Hall

Document Summary

Dna/rna turn blue, but they die so lose that colour: nuclear changes pyknosis shrinkage of nucleus karyorrhexis breakup of nuclear material karyolysis dissolution of nucleus dead cells, inflammatory infiltrate neutrophils (pmns) and macrophages ingest only see this if the organism keeps living. Morphological changes if dead, no inflammatory response after initial necrosis: mitochondrial swelling, er loses ribosomes, lysosomes break open. Releasing enzymes that break down normal proteins: need em to see mitochondrial, er and lysosomes programmed cell death physiologic or pathologic energy dependent process to switch of unneeded or damaged cells active energy dependent tightly regulated characterized by nuclear dissolving, without complete loss of membrane integrity, a cell next door would have no idea whats going on, don"t get inflammatory infiltrate. May be pathologic: elimination of genetically altered or damaged cells, system to break cells down if injured or damaged ie. dna damage, cell injury, alternative is becoming malignant or necrosis ie. feet development, apoptosis, no webbed feet.