Pathology 3240A Lecture Notes - Lecture 2: Coagulative Necrosis, Endometrial Hyperplasia, Karyorrhexis
11 Feb 2016
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Document Summary
Clinical and experimental pathology today are still grounded in the beliefs of 19th century german scientist and statesman rudolf virchow that disease arises, not in organs or tissues in general, but primarily in individual cells. Cells must react and adapt to changing internal and external environments in order to survive. When the environmental changes exceed the capacity of the cell to maintain homeostasis, we recognize cell injury. Reaction of the cell to a stress or damaging stimulus can range from a mild, completely reversible response to a long-term adaptive change in ell growth or to irreversible damage and cell death. The moment when reversible injury becomes irreversible injury, or the point of no return", cannot be well defined. These are cell membranes critical for ionic and osmotic homeostasis; mitochondria and the generation of energy via atp; protein synthesis; and cellular dna. Long-term or chronic stimuli result in different responses in the cells.
