Pathology 3240A Lecture Notes - Lecture 9: Endothelium, Cell Adhesion Molecule, Neutrophil
25 May 2016
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Increased permeability leads to more fluid leaving (i. e. fluid leaving bc of swelling/inflammation) Hundreds of rbcs; travel in big bunches making them the heaviest particle therefore traveling in the middle. Rouleaux is the very first step of margination (wbcs pushed to periphery) Wbc attach to the surface of endothelial cells. Substances that make these cams overexpressed which makes them attracted to each other. Wbcs roll over the surface of the endothelial cells and. Phagocytes eventually you want the cell to go out: Unidirectional movement of cells on a chemical gradient. Where cells have died, there are chemotactic factors (dust, dead cells, bacteria, etc. ) Bull"s eye concentrated in the middle, and around it, it progressively becomes less concentrated. Wbcs called to this area bc they have receptors that are attracted to these chemotactic factors. Cell keeps on moving to the highest concentration of the spot which is where the injury occurred. Lateral movement towards the area of injury.
