Pathology 3245B Lecture Notes - Lecture 9: James Paget, Chromatin, Nucleolus
16 Jan 2018
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Chapter 18: female genital system and breast in section on breast (pp. Myoepithelial layer beneath lining epithelium, overlying basement membrane. Reactive-inflammatory lesions: fat necrosis firm, irregular mass often superficial. Fat necrosis is important in that it may closely simulate carcinoma, both clinically and on mammographic examination. Erythema of the overlying skin skin retraction and dimpling inflammatory response includes lipid-laden histiocytes, giant cells, chronic inflammatory infiltrate resolves with fibrosis/localized scarring: mastitis. Most cases occur during lactation (particularly in primiparas). The predisposing factors are cutaneous fissures in the nipples and breast engorgement due to incomplete nursing. The usual etiologic agents of acute mastitis are staphylococci and streptococci. Dissemination of the infection occurs via dilated lymphatics and ducts. The breast becomes tense, hot, and very painful. The patient exhibits general signs and symptoms of acute infection. Axillary lymph nodes may become enlarged and tender. Differentiation from an inflammatory carcinoma of the breast may be clinically difficult.
