Pathology 3500 Lecture Notes - Lecture 21: Karyotype, Nuclear Weapon, Cell Migration

• School: Western University
• Department: Pathology
• Course: Pathology 3500
• Professor: shepherd

Document Summary

Congenital disease: presence at birth, may be secondary to a genetic etiology but also maybe not. Genetic disease: determined by genes, this can be present at any time. Congenital abnormalities: morphological defects present at birth, may or may not be a genetic basis for these defects, 3% of newborns, most common cause of mortality in the 1st year of life. Intrinsic cause for the abnormality in the development of the limb or organ: most secondary to genetic, prevented from growing normally, ex. Polydactyl, congenital heart disease: disruption, breakdown of normal development, results from secondary destruction of an organ or body region, usually extrinsic etiology ex. Amniotic band (fetus is growing normally, nothing is wrong but for some reason the amnion (inner membrane of uterus) breaks off and wraps around baby and can wrap around leg for ex. Syndrome: characteristic association of several abnormalities, caused by a single etiologic agent affecting several tissues, may or may not be sequential.