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Class Notes for Pathology at Western University

Pathology 3240A Lecture 11: Autoimmune Diseases

Lecture 11 Immune system: The bodys defense mechanism against microorganisms and their products (toxins) I) Innate immune system: Born with, not specific, does not require previous exposure to an anti...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture 10: Metabolic Diseases

Lecture 10 Metabolism: The range of biochemical processes that occur within us, or any living organism Metabolism consists of both anabolism (build-up) and catabolism (breakdown) of substances Metabolism is commonly used...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture 8: Hemodynamics

Lecture 8 INTRODUCTION 60% of human bodys weight is water. 2/3 of body fluid is intracellular, and 1/3 of body fluid is extracellular (plasma and interstitial fluid). Survival of cells and tissues is dependent on oxyg...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture 12: Congenital Diseases

Lecture 13 Perinatal Infections Transcervical (ascending) Transplacental (hematological) Transcervical Infections Come up through the vaginal canal and the cervix In Utero or during birth Common: Bacteria (beta hemo...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture 9: Molecular Genetics

Lecture 9 The central dogma of molecular biology: DNA to RNA to protein Mutations are permanent changes in DNA In germ cells: Can be transmitted to progeny; giving rise to inherited diseases, or predisposition to famili...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture 13: Perinatal Diseases

Lecture 12 Congenital Disease: Present at birth (can be due to an underlying genetic abnormality, or not) Genetic Disease: Determined by genes (can manifest at birth, childhood, teenage, or adulthood) Congenital Abnorm...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 3: Meningitis, Lipopolysaccharide, Bloodborne

Lecture 3 Infection Infectious disease occurs when a pathogenic organism causes signs and symptoms of inflammation or organ dysfunction. Kochs Postulates: Found in lesions of disease Can be isolated in vi...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 1: Eosinophilia, Endometrium, Pyknosis

Lecture 1 Cell Injury Rudolf Virchow Father of cellular pathology Everything that you see in a patient has a root cause at the cellular level Every cell comes from another cell like it Cells are constantly adjusti...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 2: Basic Fibroblast Growth Factor, Phagocyte, Collagen

Lecture 2 Inflammation Inflammation is dynamic, non-lethal, and non-specific Caused by pathogens, immune response, ischemia, etc. Leads to loss of function of affected tissue/organ The triangle of inflammation: Vessels ...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 6: Metastasis, Multiple Endocrine Neoplasia, Antigen

Lecture 6 Dysplasia: Alteration in size, shape and organization of the cellular components of a tissue Features: Variation in shape and size of cells; enlargement, irregularity and hyperchromatism of the nuclei; disorde...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 5: Anaplasia, Metastasis, Hamartoma

Lecture 5 Neoplasia Dysplasia: Alteration in size, shape and organization of the cellular components of a tissue Features: Variation in shape and size of cells; enlargement, irregularity and hyperchromatism of the nucle...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 3240A Lecture Notes - Lecture 7: Blood Transfusion, Viral Load, Pus

Lecture 7 Infectious disease occurs when a pathogenic organism causes signs and symptoms of inflammation or organ dysfunction. Kochs Postulates: Found in lesions of disease Can be isolated in vitro Ca...

Pathology
Pathology 3240A
Cheryl Campbell
Pathology 4500B Lecture Notes - Lecture 6: Morphine, Coroner, Coronary Circulation

Lec 6 Drug-related deaths: Affects personal lives, health policies, social agencies, law enforcement, death investigations Scene: Suspicious of IV drug use (needle, powder, saline, lighter) What questions...

Pathology
Pathology 4500B
Ted Tweedie
Pathology 4500B Lecture Notes - Lecture 8: Esophageal Varices, Vitreous Body, Hyperkalemia

Lec 8 Sudden Natural Unexpected Death SUDDEN o Most consider sudden as death 1 hour after onset of symptoms o Sometimes, no symptoms at all NATURAL o Due to disease ...

Pathology
Pathology 4500B
Ted Tweedie
Pathology 4500B Lecture Notes - Lecture 9: Stab Wound, Structural Integrity And Failure, List Of Internet Phenomena

Lec 9 The pathologist and firearm wounds Range estimation Recovery/Identification of projectiles Wound tract/trajectory analysis o Autopsy: Stable, wound position relative to body ...

Pathology
Pathology 4500B
Ted Tweedie

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