Pharmacology 2060A/B Lecture Notes - Lecture 5: Nephron, Renal Medulla, Distal Convoluted Tubule

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Andrea Di Sebastiano

Document Summary

Is the removal of parent drug and or drug metabolites from the body: most common site of drug excretion is in the kidney and in the bile (with most important site being the kidney) This is especially important with those with end stage kidney disease, as they require dialysis. The nephron: the basic structural and functional unit of the kidney, regulates water, electrolyte levels and drug excretion, regulates/controls blood volume we keep in our body, blood pressure, blood ph and solute (including drug) excretion. Efferent arteriole: carries blood away from glomerulus (after it has been filtrated) Afferent arteriole: carries blood to the glomerulus for filtration. Glomerulus: is a bed of capillaries that make up the first stage of filtering blood to form urine. Bo(cid:449)(cid:373)a(cid:374)"s capsule a(cid:374)d fluids a(cid:374)d solutes filtered (cid:271)y the glo(cid:373)erulus e(cid:374)ter the spa(cid:272)e i(cid:374) bo(cid:449)(cid:373)a(cid:374)"s (cid:272)apsule (cid:271)efore entering the tubules.