Pharmacology 2060A/B Lecture 9: Module 9 Pharmocodynamics Therapeutic Index

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Andrea Di Sebastiano

Document Summary

In an to medications would be exactly the same for every patient. the response: unfortunately in reality, response to medications is quite variable between patients. It"s a(cid:272)tuall(cid:455) a combination of genetics, disease state and environment that determines how a patient will respond to a drug. Ie. diet is an environmental factor, while diseases such as gi and renal diseases affect drug absorption; genetic differences such as gender and different polymorphisms also have an influence on the way we respond to drugs. Determining inter-patient variability: phase ii clinical trials establish dose-response relationships over a range of drug doses, to determine inter-patient variability in response to medications, we first set an endpoint. The ed50 is the average dose required to produce a response in 50% of the population: the ed50 is often used as the initial starting dose for therapy. When the drug has a wide therapeutic range.