Pharmacology 2060A/B Lecture Notes - Lecture 11: Acetaldehyde Dehydrogenase, Cyp2C19, Alcohol Dehydrogenase
Document Summary
The risk of drug interactions increases (almost linearly) with the number of medications a patient takes: drug interactions are especially important in the elderly. The average number of medications is higher as you get older. The average 65 year old takes 7 medications, significantly more than the average 20 year old. This is an increased risk to drug interaction (slope becomes steeper) The most common type of drug-drug interactions are those affecting pharmacokinetics (adme). 11. 2 consequences of drug interactions: when two drug or more drugs interact there are 3 possible outcomes: Increased effects: drug interactions can increase drug effects by either an increase in the therapeutic effect or an increased adverse effect. Increased therapeutic effects: ampicillin is an antibiotic that is rapidly inactivated by bacterial enzymes (making it ineffective at killing bacteria), sulbactam is an inhibitor of the bacterial enzyme that inactivates ampicillin.