Pharmacology 2060A/B Lecture Notes - Lecture 9: Frequency Response, Frequency Distribution, Analgesic

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In red toxic response to the drug. Clinical trials are an important first step in determining interpatient variability to drug response. The ed50 is the dose required to produce a response in 50% of the population: the ed50 is often used as the initial dose for therapy. To determine interpatient variability in response, we use data from phase 2 clinical trials; these are the trials that establish dose response relationships over a range of doses of the drug. The first important thing we have to do is set an endpoint that we are going to measure. In a situation where you have a wide therapeutic range, so you have a safe drug, a low risk of the pt. experiencing side effects. When the drug has a wide therapeutic range. Drugs with a narrow therapeutic range should have their dose titrated (start low and increase slowly until the desired response is achieved): most importantly, responses to medication can be quite variable.

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