Pharmacology 2060A/B Lecture Notes - Lecture 10: Histamine Receptor, Drug Allergy, Allergy
2 Apr 2018
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Adverse drug reactions can include: side effects, drug toxicity, allergic reaction. Idiosyncratic reaction: carcinogenic effects, mutagenic effects, teratogenic effects. If we look at patient on the right, being treated with anti-histamine. The histamine receptor blocker is sitting in the histamine receptor and this causes vasoconstriction which gets rid of the symptom of allergies. This patient is potentially going to have side effect which is due to the antihistamine drug acting at a different site in the body. The antihistamine binds to histamine receptors in the brain and this procures the side effect of drowsiness. In the figure, you can see that histamine binding to the histamine receptor in sinuses causes vasodilation which results in runny nose and watery eyes. Antihistamines act by blocking the effect of histamine. Side effects occur when antihistamines bind to either histamine receptors or other receptors in the brain. This produces sedation, dry mouth, and urinary retention.
