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Pharmacology (354)
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Module 4 Notes.docx

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Department
Pharmacology
Course
Pharmacology 2060A/B
Professor
Angela Nissen
Semester
Fall

Description
Module 4 NotesMetabolismenzyme mediated alteration of drug structure AKA BIOTRANSFORMATIONSitesLiverprimary siteIntestineenterocytes that line gut metabolismStomachmetabolism alcoholkidneyintestinal bacterialnormal bacterial floraExogenouswine steak coffee drugs cigarettes vegetables metabolism PREVENT TOXICITY EndogenousVit D synthesisBile acid synthesisCholesterol metabolismHormones steroidsDrug Metabolismincrease water solubility of drugs TO BE EXCRETEDo lipophilichydrophilicinactivate drugexcretemake drug more effectiveactivate PRODRUG only active after metabolismINCREASE drug toxicityFirst Order Kinetics skewed to right curveconcentration of druglower than metabolic capacity more enzymesdrug metabolismproportional to concentration of free drugconstant FRACTION of drug per unit time Zero Order Kinetics diagonal negative slope line ETHANOL alcoholconcentration of plasma drug is higher than metabolic capacitymetabolism is CONSTANTconstant AMOUNT of drug is metabolized per unit time first pass metabolismdecrease amount of parent drug that enters systemic circulationhepatocytes in liverintestinal enterocytesstomachintestinal bacteriastomachalcoholalcohol dehydrogenase acetaldehyde intestine drugCYP enzymemetabolite bacteria drugbacterial enzymesmetabolite liver drugCYP enzymemetabolite
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