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Pharmacology (354)
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Module 6 Notes.docx

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Department
Pharmacology
Course
Pharmacology 2060A/B
Professor
Angela Nissen
Semester
Fall

Description
Module 6 NotesClinical Pharmacokinetics relationship between effect and concentration of drug in bodyParametersclearance Cl body efficiency in drug elimination o volume of blood cleared per unit of time mLmin or Lhr o renal clearancehepatic clearance o total clearancesum of clearance by all routesdetermines dosage rate required to maintain blood conc DOSING RATEPLASMA CONCCLEARANCEvolume of distribution VdAPPARENT space in body to contain drugelimination half liferate of removal of drug o T12 o Time takes plasma drug to decrease to 50 o T120693VdCl o How long it will take for drug levels to decline once stop administering drug o Directly proportionate to Vd large long half life o Indirectly proportionate to Cl largeshort half life o 5 HALF LIVES TO REACH STEAD
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