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Pharmacology (354)
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Module 7 Notes.docx

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Department
Pharmacology
Course
Pharmacology 2060A/B
Professor
Angela Nissen
Semester
Fall

Description
Module 7Pharmacokinetics what the body does to the drug Pharmacodynamics what the drug does to the body Increase does increases responseY axis response xaxis doseMONOTONICresponse increases as dose increases o NOT LINEAR o Hence we use SEMILOGARITHMIC PLOTPhase 1 dose too low to elicit response Phase 2 response is graded and nearly linear Phase 3 plateaularger doses do not lead to larger responses may lead to toxicityEfficacy HIGHERhow effective drug is at given dosemax efficacymax effect higher on dose curvehigher max efficacy CHOOSE drug and dosetherapeutically effective and fewest side effects o Not max effectiveTitrate drugstart with low dose and slowly increase Potency more potentLEFTamount of drug required to elicit pharma responsehigh potency does NOT mean more therapeutic
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