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Module 11 Notes.docx

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Western University
Pharmacology 2060A/B
Angela Nissen

Module 11 Drug Interactions - interact with each other drugs or food from diet - 2+ drugs, linear increase with number of drugs o increase effect, decrease effect, whole new effect - 1+ drugs with food interaction - elderly over 65 age take 7 meds on average - most common drug interaction are those affecting pharmacokinetics Increase Effect - increased therapeutic Effect o ampicillin  poor therapeutic response, antibiotic inactivated by bacterial enzymes o sulbactam  inhibitor of bacterial enzyme that inactivates ampicillin o ampicillin + sulbactam  increased therapeutic activity of ampicillin - Increased adverse effect o Warfarin  anticoagulant used to thin blood o Aspirin  analgesic also thins blood o Warfarin alone  effective blood thinner o Warfarin + aspirin  excessive bleeding (potentially life threatening) Decreased Effect - reduced therapeutic effect o clopidogrel anticoagulant, thin blood, requires metabolic activation by cup2c19, decrease CV events o omeprazole inhibits cyp2c19 o given together  clopidogrel not formed, increased CV events - reduced adverse effect o morphine  analgesic treat pain o morphine overdose  coma, respiratory depression, de
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