Pharmacology 2060A/B Lecture Notes - Isoniazid, Codeine, Caffeine

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Angela Nissen

Document Summary

Active (cid:0) inactive: increase drug effectiveness. Active (cid:0) more active: activate prodrugs (prodrugs are inactive until metabolized) Prodrug (inactive) (cid:0) active drug: increase drug toxicity. 4. 2 kinetics of drug metabolism: first order, in most clinical situations the concentration of drug is much lower than the metabolic capacity of the body. Po doses are usually much higher than iv doses (to compensate for high first metabolism) Small changes in hepatic enzyme activity produce large changes in bioavailability. First pass through liver results in high metabolism rate. Very susceptible to drug-drug interactions: low er drugs. Po doses are usually similar to iv doses. Small changes in hepatic enzyme activity have little effect on bioavailability. Take many passes through liver via systemic circulation before they are completely metabolized. 4. 4 types of drug metabolism: drug metabolism is broadly divided into 2 phases (phase i metabolism and phase.