Pharmacology 3620 Lecture Notes - Lecture 25: Migraine, Monoamine Oxidase, Angina Pectoris

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Brad Urquhart

Document Summary

Also a hormone released from the adrenal glands (but its role is less important as a hormone) Has a methyl group on the lamine. Released at the sympathetic postganglionic neurons (ne) and by the adrenal medulla (ne and e) This benzene ring with two hydroxyls is referred to as catechol. This is why both norepinephrine and epinephrine are catecholamines. Adds a third hydroxyl group on the -carbon. Add a methyl group on to the amine. Norepinephrine and epinephrine are the endogenous ligands. Isoproterenol is an example of an exogenous mimetic drug receptors. Affinity for e > ne > isoproterenol. Affinity for isoproterenol > ne > e. Now we recognize 9 subtypes and receptors was a major advance. We only need to understand the 4 subtypes. To increase increase the probably ca2+ channels are open and therefore increase [ca2+]i. To decrease increase the probably ca2+ channels are open and therefore decrease [ca2+]i.