Pharmacology 3620 Lecture Notes - Lecture 20: Pyridoxine, Huntingtin, Monoamine Oxidase Inhibitor
25 Apr 2018
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Document Summary
Motor system disorder due to the loss of dopamine-producing brain cells. Four primary symptoms: slowness and difficulty in coordinating movements. Tremor in hands, arms, legs, jaw and face. Rigidity or stiffness of the limbs and trunks. Postural instability or impaired balance and coordination. As the symptoms become more pronounced patients may have difficulty walking, talking, or completing other simple tasks. Shaking/tremor may begin to interfere with daily activities. Difficulty in swallowing, chewing and speaking, urinary problems or constipation, skin problems and sleep disruption. Parkinson"s disease is caused by the loss of dopamine neurons located in the lower brain called the substantia nigra (a9 system) Lewy bodies aggregates inside nerve cells in parkinson"s. Dopamine content decrease can be seen in pet scans. Dopaminergic neurons in the substantia nigra project into the neostriatum. Excites inhibitory gaba neurons that feedback to the dopaminergic neurons. Loss of inhibitory dopaminergic signals sult in excess ach and triggers abnormal signaling.
