Pharmacology 3620 Lecture Notes - Lecture 15: Endocytosis, Phenytoin, Gabapentin
25 Apr 2018
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Document Summary
A seizure is an abnormal synchronization of electrical neuronal activity in the brain. Brain normally synchronized electrical activity in sleep. However, in seizures the synchronizations are bigger and more widespread than what it should be. High amplitude, synchronized activity across the entire brain. Can result in the loss of consciousness. Motor activity can be involved or not. Untreated seizures tend to generate more seizures. Epileptic seizure is synchronous neuronal activity in the brain. Having seizures, at some frequency, all the time. A transient occurrence of signs and/or symptoms due to abnormal excessive or. 0. 5% -1% of the world population have some form of epilepsy. Usually non-fatal although acute seizures can cause sudden death (sudep) Life long affliction with very low spontaneous reversion rate. One of the most costly health care burdens in the western world. Little or no evidence of localized onset. Usually seizure activity is in a region of one cerebral hemisphere.
