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Class Notes for Pharmacology at Western University

Pharmacology 2060A/B Lecture Notes - Lecture 1: Natural Health Product, Pharmacology, Antibody
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Pharm 2060B Lecture 1 Introduction to Pharmacology 1. Introduction a. What is Pharmacology? i. The word pharmacology is derived from the greek words pharmakon meaning remedy and logos meaning study. Generally pharmacology ...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 4620A Lecture Notes - Lecture 5: Glycogen Phosphorylase, G Protein-Coupled Receptor Kinase, Threonine
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Lecture 5: Kinases and RTKs There are 2 family of kinases Large family of Serine-Threonine kinases Thought that this was the only target at first Ex. GRKs Small tyrosine kinases ...

Pharmacology
Pharmacology 4620A
Gideon Koren
Pharmacology 4620A Lecture Notes - Lecture 1: Drug Discovery, Lead Compound, Transcription Activator-Like Effector Nuclease
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Lecture 1: Molecular and Structural Basis of Drug Action Overview of Drug Discovery Process Historical Source of Drugs Target based rational drug discovery Examples of HTS screening assays Identifica...

Pharmacology
Pharmacology 4620A
Gideon Koren
Pharmacology 4620A Lecture Notes - Lecture 3: Gut Flora, Microbiota, Quinine
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Lecture 3: GPCRs 1 GPCR ligands are physically and chemically diverse Photons Photo-rhodopsin Ions ZInc Ordorants Neurobiological network rather than a single ligand-r...

Pharmacology
Pharmacology 4620A
Gideon Koren
Pharmacology 4620A Lecture Notes - Lecture 2: Lipid Bilayer, Biotransformation, Partition Coefficient
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Lecture 2: Pharmacokinetics and Pharmacodynamics Bioavailability: Fraction of drug that reaches circulation in an unchanged form (liberation of the drug) Changed to achieve different goals Long onset, s...

Pharmacology
Pharmacology 4620A
Gideon Koren
Pharmacology 4620A Lecture Notes - Lecture 4: Homologous Desensitization, Adenylyl Cyclase, Adrenergic Receptor
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Lecture 4: GPRCs 2 GPCR Desensitization Desensitization Tendency for a biological response to diminish over time despite the constant presence of a stimulus (agonist) of constant intensity...

Pharmacology
Pharmacology 4620A
Gideon Koren
Pharmacology 2060A/B Lecture Notes - Lecture 13: Blood Pressure, Pheochromocytoma, Sphygmomanometer
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PHARM MODULE 13 DRUGS FOR HYPERTENSION 13.1 HYPERTENSION (high bp) Hypertension is simply defined as elevated systemic arterial blood pressure. Blood pressure is a measurement of the force against...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 12: Coronary Artery Disease, Hypercholesterolemia, Apolipoprotein
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Pharm Module 12 Drugs To Lower Cholesterol And Triglycerides 12.1 INTRO Coronary Heart Disease Coronary heart disease occurs when coronary blood circulation fails to adequately supply the heart with bloo...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 10: Histamine Receptor, Urinary Retention, Adverse Drug Reaction
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Pharm Module 10 ADVERSE DRUG REACTIONS AND MEDICATION ERRORS 10.1 ADVERSE DRUG REACTIONS Adverse drug reactions (ADRs): unintended and undesired responses from drugs. Are an enormous societal health prob...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 11: Liver Function Tests, Rifampicin, Cyp2E1
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Pharm Module 11 DRUG INTERACTIONS 11.1 INTRO Drugs can interact with each other or components in our diet to produce complicated responses. Drug-drug interactions may occur whenever a patient takes two or more drugs. Drug-...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 9: Frequency Distribution, Analgesic, Cardiac Arrhythmia
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Pharm Module 9 PHARMACODYNAMICS: THERAPEUTIC INDEX 9.1 INTERPATIENT VARIABILITY IN RESPONSE In an ideal world the response to medications would be the same for every patient. Unfortunately in reality, ...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 7: Logarithmic Scale, Pharmacodynamics, Pharmacokinetics
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Pharm Module 7 PHARMACODYNAMICS DOSE RESPONSE RELATIONSHIPS 7.1 INTRODUCTION Pharmacodynamics is the study of what the drug does to the body. Remember that pharmacokinetics is what the body does ...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 8: Intrinsic Activity, Receptor Antagonist, Partial Agonist
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Pharm Module 8 PHARMACODYNAMICS DRUG RECEPTOR INTERACTIONS 8.1 THEORIES OF DRUG RECEPTOR INTERACTIONS In the last module we learned that most drugs work by binding to receptors. Is simply occupyin...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 5: Distal Convoluted Tubule, Proximal Tubule, Kidney Disease
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PHARMACOKINETICS EXCRETION 5.1 ROUTES OF DRUG EXCRETION Drug Excretion Is the removal of parent drug and drug metabolites from the body Most common sites of drug excretion are the kidney and the bile ...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano
Pharmacology 2060A/B Lecture Notes - Lecture 6: Pharmacokinetics, Circulatory System, Bioavailability
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Pharm Module 6 CLINICAL PHARMACOKINETICS: TIME COURSE OF DRUG ACTION 6.1 CLINICAL PHARMACOKINETICS The underlying principle of clinical pharmacokinetics is that a relationship exists between the effects o...

Pharmacology
Pharmacology 2060A/B
Andrea Di Sebastiano

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