Pharmacology 2060A/B Lecture Notes - Lecture 5: Enterohepatic Circulation, Proximal Tubule, Nephron

111 views4 pages

Document Summary

Is the removal of parent drug and drug metabolites from the body. The kidneys account for the majority of drug excretion. Healthy kidneys serve to limit the duration and intensity of drug effects. Decreased kidney function prolongs the duration of action and intensity of drug effects. The basic structural and functional unit of the kidney. Controls blood volume, blood pressure, blood ph and solute (including drug) excretion. Drugs enter the kidney from the renal artery. Hydrostatic pressure within the glomerular capillaries force low molecular weight drugs into the renal tubules. 120 ml/min/1. 73m2 or about 20% of total renal plasma flow. Lipid solubility and ph do not affect glomerular filtration of drugs. Only non protein bound (i. e. free) drugs are filtered at the glomerulus. Drugs not filtered by the glomerulus leave the glomerulus by the efferent arteriole. The efferent arterioles divide to form capillaries that surround the proximal tubule.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Questions