Pharmacology 2060A/B Lecture Notes - Lecture 5: Cardiac Output, Circulatory System, Half-Life
25 Apr 2018
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5. 1 drug excretion: is the removal of parent drug & drug metabolites from the body, 4 sites, kidney, bile, lung, breast milk. Renal drug excretion: the kidneys account for majority of de, healthy kidneys limit the duration & intensity of drug effects, decreased kidney functions prolong drug effects and amplifies their intensity. The nephron: is the basic structural & functional unit of the kidney, regulates water, electrolyte, and de, controls blood volume, blood pressure, blood ph, solute (including drug) excretion, components. 5. 4 pulmonary drug excretion: drugs eliminated by pulmonary excretion are often gaseous and/or volatile, e. g. General anesthetics: pde is not heavily reliant on drug metabolism, factors affecting pde, respiration rate, cardiac output, drug solubility in blood. Hair: drugs can be excreted into hair follicles, drugs can be measured in hair to determine how long a person is exposed, important implication for forensics, hair grows ~1cm per month.
