Pharmacology 2060A/B Lecture Notes - Lecture 2: Suppository, Anticholinergic, Vagus Nerve

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Andrea Di Sebastiano

Document Summary

Introduction: module objectives: basic processes involved in pharmacokinetics, difference between enteral and parenteral, advantages and disadvantages of various administration routes, barriers to absorption for each route of administration. Pharmacokinetics: study of drug movement inside the body, composed of 4 basic processes: Excretion: (cid:862)what the (cid:271)ody does to the drug(cid:863) Absorption: drug absorption- movement of drug from administration site into blood, rate of absorption determines how quickly the drug will take effect / onset of action, amount of drug absorption determines the intensity of drug effect. Factors affecting drug absorption: rate of dissolution, dissolution dissolving in solution, drugs must be dissolved before being absorbed, faster rate of dissolution = faster onset of action. Figure 1: dissolution occurring over time: surface area to which drug is applied. Is the greatest determinant of drug absorption: larger surface area = faster drug absorption, size comparison: stomach vs. small intestine. Stomach has folds called rugae resulting in a relatively small surface area.