Pharmacology 2060A/B Lecture Notes - Tachyphylaxis, Intrinsic Activity, Agonist
3 Mar 2014
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Is simply occupying the receptor enough to elicit a response: what if two drugs occupied the same number of the same receptor, would the response be the same, two receptor theories to describe drug receptor interactions, the simple occupancy theory, the modified occupancy theory, simple occupancy theory, the intensity of a drugs response is proportional to the number of receptors occupied, the maximal response occurs when all the receptors are occupied, this implies that two drugs that act at the same receptor should produce the same effect. Affinity attraction that a drug has for its receptor. Drugs with a high affinity are highly attracted to their receptor and therefore bind effectively even at low concentrations. Low affinity drugs are weakly attracted to their receptor and bind ineffectively even at high concentrations. Affinity of the drug is the primary determinant of the drugs potency: drugs with high affinity have high potency, modified occupancy theory intrinsic activity.
