Pharmacology 2060A/B Lecture Notes - Sauerkraut, Warfarin, Tachycardia

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Angela Nissen

Document Summary

Morphine analgesic used to treat pain: overdose (cid:224) produces coma, respiratory depression and even death, treating morphine overdose (cid:224) naloxone (antagonist, generation of new effect, unusual, disulfiram helps treat chronic alcoholism, alcohol normally metabolized to acetaldehyde and then to acetic acid. Chelation/binding: some drugs bind other drugs in intestine, causing formation of insoluble complexes that cant be absorbed, bile acid sequestrants, designed to bind bile acids and prevent absorption from intestine, cholestyramine bile acid complex is excreted in feces, bile acid sequestrant cholestyramine binds to digoxin in intestine and. Altered blood flow decreases its absorption only free digoxin is absorbed into blood: blood flow influences absorption, drugs that decrease blood flow decrease absorption of drugs, epinephrine (with a local anaesthetic, if administered alone, may diffuse into blood away from injection site, if injected with a local anaesthetic, causes vasoconstriction and decreases absorption of local anaesthetic.