Pharmacology 2060A/B Lecture Notes - Lecture 2: Angina Pectoris, Antacid, Drug Metabolism
To understand the basic processes involved in pharmacokinetics. To appreciate the difference between enteral and parenteral. To understand the advantages and disadvantages of various routes of administration. Appreciation of the barriers to absorption for each of the routes of administration. Is defined as the study of drug movement in the body. Is what the body does to the drug (adme) Pharmacokinetics is composed of four basic processes: absorption, distribution, metabolism, excretion. Absorption: drug absorption is the movement of the drug from the site of administration into the blood. The rate of absorption determines the onset of action or how quickly the drug effect will occur. The amount of drug absorption determines how intense the effect of the drug will be. Surface area is a major determinant of drug absorption. Blood flow: drug absorption is fastest in areas with high blood flow. Areas with a high blood flow maintain a concentration gradient which drives absorption.