Pharmacology 3620 Lecture Notes - Lecture 8: Point Mutation, Threonine, Neuromuscular-Blocking Drug

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Determine the implications of variability in drug response. Pharmacogenetics is the study of the genetic basis for variation in drug response. The first studies of relevance to pharmacogenetics occurred in the 1930s. These related not to drugs but the genetic control of a taste response. The term pharmacogenetics was coined in 1959 by friederich vogel. Werner kalow at the university of toronto was one of the pioneers of pharmacogenetics (more later) The human genome project was published in february 2001. This revolutionized many areas in medicine including pharmacogenetics and the idea of personalized medicine . Pharmacogenetics relates our dna to pharmacokinetics, pharmacodynamics and drug response: i. e. the impact of genetic variation on pk and pd. Identify three primary components that play a role in the variability of drug response. Variation in drug response determined by 3 major components: disease, environment, genetics.

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