Pharmacology 3620 Lecture Notes - Lecture 35: Antibody, Palpation, Half-Life
24 Mar 2017
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Document Summary
In hyperthyroidism, the expression of epinephrine receptors are increased, which causes hyperresponsiveness to epinephrine. Thyrotropin-releasing hormone (trh) stimulates endocrine cells of anterior pituitary to secrete thyroid-stimulating hormone (tsh) Tsh binds receptors on thyroid follicle cells to increase synthesis of thyroid hormones. Thyroid gland is not essential for adult life, but is important. Thyroid hormone receptors are present in the nuclei of most cells in the body. Simulation of na/k atpase activity: release of fatty acids from adipocytes, carbohydrate absorption from intestines, upregulation of -adrenergic receptors in many tissues (incl. heart and nervous system) hyperresponsiveness to epinephrine. Through these mechanisms, thyroid hormone is responsible for about 20% of resting oxygen consumption. & associated body heat generation: maintaining constant levels of thyroid hormones depends on their negative feedback effects, which inhibits synthesis and secretion of tsh and trh. The thyroid gland is comprised of follicles containing colloid (proteinaceous substance from which thyroid hormones are produced) surrounded by thyroid/follicle cells.
