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Lecture

Transport mechanisms

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Department
Physiology
Course Code
Physiology 3120
Professor
Tom Stavraky

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Human Physiology Friday, September 18, 2009 Membrane Transport Mechanisms • Secondary active transport  Concentration gradients of Na and K can be used to power other mechanisms (moving substances down the gradient releases energy, which can be used for other things)  Na/K pump on basal membrane (away from external environment)  On luminal side, sodium allowed to come in down its concentration gradient  Glucose brought into the cell along with Na using the sodium/glucose cotransporter (ratio of transport?)  Also have sodium/+ydrogen exchanger (Na comes in down its gradient, which provides energy to pump H ions out)  Indirectly requires ATP (requires ATP to maintain the concentration gradients)  Polarized transport  Different mechanisms on one side compared to the other side  Allow for unidirectional transport in/out of body fluids • Similarities & differences between all transport mechanisms (study tip!!) • Osmosis: movement of water down its concentration gradient due to its thermal motion (i.e. diffusion of water)  Water concentration is determined by the numbe
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