Physiology 3120 Lecture Notes - Starling Equation, Extracellular Fluid, Colloid

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If you add an isotonic nacl load, there will be an increase in volume in the ecf, but no osmosis will occur because there is no concentration gradient: site of exchange is the capillary endothelium. Thus the composition of the interstitial fluid & the plasma is very similar. Filtration = movement out of the capillary. Pressure from the blood in the capillary. Varies from one end to the other (25mmhg to 10mmhg) Promotes filtration: interstitial fluid hydrostatic pressure (pif) Pressure on the fluid in the interstitial space. Varies from organ to organ (-6 to +6 mmhg) Can cause filtration (when pressure is negative) or reabsorption (when pressure is positive: interstitial colloid osmotic (oncotic) pressure ( if) Pressure caused by osmosis due to proteins in the interstitial space. Causes filtration: plasma colloid osmotic (oncotic) pressure ( p) Pressure caused by osmosis due to proteins in the plasma. Nfm = kf [ (pc pif) ( p if) ]

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