Physiology 3120 Lecture Notes - Starling Equation, Extracellular Fluid, Colloid
Document Summary
If you add an isotonic nacl load, there will be an increase in volume in the ecf, but no osmosis will occur because there is no concentration gradient: site of exchange is the capillary endothelium. Thus the composition of the interstitial fluid & the plasma is very similar. Filtration = movement out of the capillary. Pressure from the blood in the capillary. Varies from one end to the other (25mmhg to 10mmhg) Promotes filtration: interstitial fluid hydrostatic pressure (pif) Pressure on the fluid in the interstitial space. Varies from organ to organ (-6 to +6 mmhg) Can cause filtration (when pressure is negative) or reabsorption (when pressure is positive: interstitial colloid osmotic (oncotic) pressure ( if) Pressure caused by osmosis due to proteins in the interstitial space. Causes filtration: plasma colloid osmotic (oncotic) pressure ( p) Pressure caused by osmosis due to proteins in the plasma. Nfm = kf [ (pc pif) ( p if) ]