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Regulation of renin release

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Western University
Physiology 3120
Tom Stavraky

Human Physiology Friday, December 4, 2009 “Renal VI” Regulation of Renin Release 1. Baroreceptors a. Carotid sinus  When Na is low, ECF decreases and so does BP  Baroreceptors in carotid sinus innervate the juxtaglomerular cells (neural reflex)  Fewer APs in baroreceptors; stimulates juxtaglomerular cells to release renin b. Intrarenal  When BP decreases, juxtaglomerular cells beside afferent arteriole deform less and therefore secrete renin 2. Chemoreceptors  Cells in macula densa can detect levels of NaCl in filtrate  Decrease in Na stimulates juxtaglomerular cells nearby to release renin Regulation of Aldosterone Release 1. Angiotensin II 2. Potassium  High levels of potassium in blood directly stimulates adrenal gland to produce & release aldosterone 3. Adrenal Corticotropic Hormone (ACTH)  Hormone that is released by anterior pituitary gland Atrial Natriuretic Peptide (ANP) • Peptide hormone (charged) made by cardiac atrial cells • Inhibits Na reabsorption • Released when cardiac cells distended; activated by stretch receptors (increased BP and ECF volume) • Inhibits aldosterone release, which prevents Na reabsorption; also, increases GFR by dilating the afferent arteriole (i.e. more filtrate, more salt excreted) Filtrate Concentration • Fil
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