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Excitation-contraction coupling - CV

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Physiology 3120
Tom Stavraky

Human PhysiologyFriday January 15 2010CV VIExcitationContraction CouplingCa required for contraction but Ca can be highly toxic in high amounts Ca compartments inside the cardiac cell sarcoplasmic reticulum SR ensure that a source of Ca is close to the muscleCa transport mechanismsSarcolemmaCa channels dihydropyridine DHP receptor brings Ca IN this is how Ca enters during the plateau phaseNaCa exchanger moves Ca OUT also capable of bringing Ca in using the concentration gradient of Na 3 Na in exchange for 1 CaCa pump ATPase moves Ca OUT relatively smallaccessory roleSR storageCa pump ATPase moves Ca into SR 1 mole of ATP moves 2 moles of CaPhospholambin is an inhibitor of the pump regulates Ca pumpCa channel ryanodine receptor lets Ca OUT Ca is able to induce Ca release through this channelSequenceAP arrives which opens DHPRCa rushes in and binds to ryanodine receptorCa released and binds to troponin C in myofibrils causing contractionCa dissociates and most gets pumped back into SR and some is pumped into the ECF by the other transportersVentricular muscle temporal relationshipsVentricular
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