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CV regulation 2

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Physiology 3120
Tom Stavraky

Human Physiology Wednesday, January 27, 2010 “CV XI” Other Mechanisms of CV Regulation • Emotional stress (i.e. joy, excitement, sorrow, anger, humiliation, embarrassment, etc.)  Induces rapid adjustments of CV function  Involves cortico-hypothalamic centres  If people suffer from long-term stress/anger, it could damage the CV system  Stressful situations stimulates release of cortisol (induces glucose release from liver); if constantly stimulated, can lead to stress-induced hyperglycemia; can destroy endothelial cells lining vascular walls, leading to hypertension and later heart failure  To determine HR (in bpm), look at RR interval on ECG and divide 60 by that value  Mechanisms. . .  Increases sweat gland output  Vasodilation of muscle arterioles  Stimulation of adrenal medulla, which secretes ACh and further dilates muscle arterioles  Less cholinergic inhibition of heart, so HR rises  More blood diverted to skeletal muscle  Vasovagal syncope (fainting due to stress)  Some people receive unexpected, sudden vagal stimulation of the heart  decreases HR and mean arterial pressure  Less blood goes to brain  loss of consciousness and fainting • Exercise  CV response ensures (I) active muscle receive adequate blood, (II) heat eliminated from active muscle, and (III) blood to heart & brain isn’t compromised
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