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Stomach secretion

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Physiology 3120
Tom Stavraky

Human Physiology Monday, March 22, 2010 “Gastrointestinal II” Stomach Secretion • Functionally different regions (look the same, but different functions)  Proximal part (2/3 of total volume) = oxyntic gland area  Has major exocrine secretory role (major product is HCl) • Secreted actively by H/K ATPase that pumps against a tremendous concentration gradient (pH of plasma = 7; pH of stomach acid may be as low as 1) that is 1,000,000 to 1  The cell that produces HCl is called the oxyntic/parietal cell • Diffuse scattering of cells throughout mucosa (i.e. there isn’t a distinct gland)  Distal part (1/3 of total volume) = pyloric gland area  Small exocrine function, but its major function is endocrine; the hormone released is gastrin (eventually released into vasculature)  Gastrin circulates in the blood and gets to the oxyntic cells; has a stimulatory effect on HCl secretion  The cell that releases gastrin is called the G cell; also randomly distributed throughout pyloric gland area • Regulation of acid secretion  Typically, acid secretion is broken down into 3 phases, divided based on where the stimulation is at any point in time; food is the primary stimulation for any area of the GI tract  Not a sequential process; may have all 3 phases activated simultaneously 1. Cephalic phase  Refers to the brain  Any stimulation in the region of the brain stimulate
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