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Lecture

Gastric secretion

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Department
Physiology
Course
Physiology 3120
Professor
Tom Stavraky
Semester
Winter

Description
Human Physiology Wednesday, March 24, 2010 “Gastro III” Gastric Acid Secretion 2. Gastric phase  Occurs after food has entered the stomach and sits there  Perceptive input has been removed  2 ways to modulate acid secretion during this phase a. Physical presence of the food mass, which causes mechanical stretching of the stomach wall o Distension of stomach increases acid secretion; put balloon in stomach and inflate it  increases acid i. Primarily due to nervous reflexes; activate stretch receptors within muscle and mucosa that can activate a vagal afferent-efferent reflex pathway; this releases ACh and gastrin; called the vago-vagal reflex ii. Within the wall of the stomach, have enteric nervous system (cholinergic); it is a plexus (connects around the entire gut) that receives information from stretch receptors; enteric nerves synapse on the oxyntic cells, and receives information from stretch receptors o The enteric-mediated responses are inter-regional as well as intra-regional; can stimulate in oxyntic area and get responses in oxyntic and pyloric gland area b. Chemical caused by some of the foodstuffs o Most potent stimulus is protein or even small peptides; seems that the cells respond directly to these compounds to activate secretion of their compounds 3. Intestinal phase
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