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Gastro 1.docx

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Physiology 3120
Barry Tepperman

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Gastro 1- Mar. 21/12 - Teppermen Gut is the largest endocrine organ in the body. It contains within its wall a nervous system that functions independently of the central nervous system. Gut receives over 1/3 of total cardiac output so it influences cardiovascular system. And effect on electrolytes thus influences respiratory and renal system. GI tract: Secretes, moves, digests and absorbs. Look at first function = secretion – look at most of all secretory organs. 1) Salivary glands – 3 pairs of salivary glands (parotid, submandibular, sublingual- major). Salivary output is large – 1L to 1.5L – most during daytime. Why? If you had to classify the salivary glands? Why do we need them? They are primarily digestive glands and since we eat during daylight hours. What we learn is in most mammals (humans). Salivary output in human and the composition is different than a rodent or a cat or dog, etc. Because it depends upon the diet. They adapt to the diet. a. Each juice coming from eat kind of salivary gland is different. b. Converging duct system. What it means is that you start with in the gland, thousands and millions of them that drain into many ducts. They fuse to form a smaller number but larger diameter duct, and then to one main secretory duct. Large number of primary ducts, to one main large one. Exocrine: out of the body into a duct. It means into a duct. Out of. Endocrine means into the body/ blood. Inside of the duct is actually outside the body. c. Salivon is the functional unit. It functions a lot like the nephron. At the closed end of the system, they have acinar cells. They form a space called the acinus. It’s in the acinus that primary saliva is formed. You have intercalated duct and on the basolateral side (luminal side = lumen is a space = space inside the duct. On the basolateral side, you have these stripes and so it’s called the striated duct. Those microvilli has a lot of mitochondria which makes ATP, which is for
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