Physiology 3120 Lecture Notes - Ascending Limb Of Loop Of Henle, Distal Convoluted Tubule, Tubuloglomerular Feedback

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Functions of the kidney: ion regulation and osmoregulation, waste management, hormone production, gluconeogenesis. Glomerular filtration the bulk flow of protein-free plasma from the glomerulus into. Glomerular filtration rate the volume of fluid filtered per unit time into bowman"s space expressed in ml/min or l/day. The gfr is very constant because of the myogenic principle and tubulo-glomerular feedback. Clearance the total volume of plasma that is completely cleared of a substance and passed out in the urine and is expressed in l/day. Substance must be freely filtered, not absorbed and not secreted. Can use inulin, or creatinine ([c] is slightly over-estimated and is secreted to a minor extent) (creatinine excretion stays constant) Tubulo-glomerular feedback, higher transport of na or cli in the macula densa cells causes formation of adenosice which is released and constricts the afferent arteriole. Amount reabsorbed = filtered load amount excreted.