Physiology 3120 Lecture Notes - Bone Resorption, Dexamethasone, Epiphyseal Plate
20 Nov 2012
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Melatonin dose-dependently augmented proteins that are incorporated into the bone matrix, like procollagen type i c-peptide. Osteoprotegerin, an osteoblastic protein that inhibits the differentiation of osteoclasts is also augmented by melatonin in vitro. Another possible target cell for melatonin is the osteoclast, which degrades bone partly by generating free radicals. Melatonin through its free radical scavenger and antioxidant properties may impair osteoclast activity and bone resorption http://apps. isiknowledge. com/citedfullrecord. do? product=wos&db_id=wos&sid=1c@l43dgnh1kglikeia&search_mode=citedfull. Role of cholesterol in the regulation of growth plate. The majority of the long bones of the body (including the tibia) form through a process called endochondral ossification. A cartilage template is first formed in development and is then replaced by bone. For continued growth of these bones, a cartilaginous growth plate persists until the end of puberty in humans, and is responsible for longitudinal growth. A multitude of hormones and other proteins regulate these processes and can increase or decrease growth rate.
