Physiology 3140A Lecture Notes - Lecture 25: Karyopherin, Metastasis, Atherosclerosis
28 Dec 2017
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Involved in cell response to stress: assembly of signal recognition particles. Made up of two phospholipid bilayers (outer and inner membrane) Nuclear pores are spread throughout the membrane. The outer is continuous with the endoplasmic reticulum: membrane extends and forms the er. Nucleus must maintain its structure to keep the dna organized. Structural support on inner surface by the nuclear lamina: lamins: proteins that maintain nucleus structure. Mostly made up of lamins and lamin associated proteins (lap1, lap2, emerin) Lamins and lamin associated proteins are connected to chromatin and dna in the nucleus: by keeping chromatin attached to the nuclear lamina, it keeps it organized in certain positions. Lamins: connect to the inner nuclear membrane, connect to chromatin, connected to intermediate filaments (nesprin) which extend to the plasma membrane so the nucleus can respond to signaling pathways directly from the cell membrane. Type of intermediate filament found in the nucleus.
