Physiology 3120 Lecture Notes - Lecture 6: Ascending Limb Of Loop Of Henle, Vasoconstriction, Proximal Tubule

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Detection of low sodium by: baroreceptors. Carotid sinus baroreceptor that reflex to juxtaglomerular (jg) Jg cells are also intrarenal baroreceptors: chemoreceptors. Macula densa cells which release a paracrine factor. Paracrine factor promote or inhibit renin release. Jg is also innervated by sns (nt norepinephrine) Jg integrates the 3 info it receives to determine if renin is released and how much i. e. low bp in sns. This combination results in the most release of. Macula densa can sense nacl content of the lumen due to the activity of the nkcc multi-porter. Tubuloglomerular feedback: when higher levels of nacl, macula densa cells release atp (cleaved to adenosine) Gfr decrease: when lower levels of nacl, macula densa cells release nitric oxide (no) When nacl levels are higher, atp is released (cleaved to adenosine: both atp and adenosine bind to jg cells via purinergic receptors to inhibit renin release, raas pathway not activated.