Physiology 3120 Lecture Notes - Lecture 1: Seminiferous Tubule, Sertoli Cell, Leydig Cell

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Male Reproductive System
Lecture 1
Reproductive System: Function
Produce hormones
Produce reproductive cells (gametes)
Not responsible for homeostasis!
Male Anatomy
Scrotum: temperature regulation (35-36oC)
1. Muscles that move it up and down
2. Current exchange
as arterial blood goes down, venous blood goes up
arterial blood is warm & venous blood is cold
by the time arterial blood reaches the testes, its cooler & keeps testes
cooler than the abdominal cavity
10% of ejaculate is sperm
Accessory Glands
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Prostaglandins: SM contraction help propel it into female reproductive
o Once inside, motility will take over + SM contraction of female reproductive
o Alkaline fluid helps protect sperm from the acidic vaginal environment
Semenogelin: ensures that sperm are kept together to get to the female
reproductive tract
Testes Anatomy
Testes: a mess of seminiferous tubule
Epididymus: sperm storage & maturation
Location for Spermatogenesis
Epididymus
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Sertoli cells are not perfused by blood bc of the BM that separates it from BVs
Leydig cells are perfused by blood
o Gets all the nutrients and precursors that it needs for spermatogenesis
o Their products then move to sertoli cells
Spermatogenesis (Gamete Production)
Spermatogenesis
Spermatogonia divide by
mitosis or differentiate
into spermatocytes
The walls of the
seminiferous tubules
consist of diploid
spermatogonia
Meiosis of each primary
spermatocyte produces 4
haploid spermatids
Then the spermatids
differentiate
(mature/spermiogenesis)
and are released as sperm
22 autosomal
chromosome & 1 sex
chromosome (x or y)
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