Physiology 3120 Lecture 11: Complete Endocrine Physiology
24 Mar 2017
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Receptor has multiple effects, amplification: mechanism to achieve specificity: wiring (where nerves innervated) vs. receptors, hormone types, peptide/polypeptide, small monomers ex. Trh (3 aa: large multimeric proteins ex. Tsh, fsh, lh (200+ aa: water soluble can circulate in blood, ex. Levels ot pth produced from parathyroid gland acts on a bone (b) and bone increases. Calcium which then circulates in blood then high ca will stop pth (calcium sensitive receptors on pth: negative feedback between antagonistic pair of hormones. Dont want blood glucose to get too low or high. Two hormones act antagonistically to control, two tissues, alpha cells of pancreas glucagon, beta cells of pancreas - insulin. If glucose becomes too high - sensed by beta cells which secrete insulin, insulin then lowers circulating blood glucose, but if opposite - detected by alpha - secrete glucagon (^ prod glucose) Armstrong did: each cell expresses its own unique complement of receptors and second messengers.
