Physiology 3120 Lecture Notes - Lecture 5: Bile Canaliculus, Bile Acid, Cystic Duct

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Bile solution is made by the liver: hepatic duct cystic duct gallbladder. Bile solution is concentrated and stored in the gallbladder until it is stimulated for release (presence of meal) Water and ions within the bile solution are absorbed leaving behind bile salts, cholesterol and bilirubin. Bile duct: brings bile away from liver to gallbladder. Hepatocytes: main cell type of liver: organized in plates (hepatic laminae) & exposed to sinusoids contents, blood contents are processed by hepatocytes. Full of enzymes so they can modify them: nutrients from gi tract can be metabolized. Turn all monosaccharides into glucose & put it back into the blood to distribute to rest of body. Sinusoids: small bvs that provide o2 and nutrient-rich blood to hepatocytes (mixing of the 2 types of blood again) Bile canaliculi: where secretions of hepatocytes go into and drains into bile duct: destined to go into duodenum. Immune function: resident macrophages within the liver.

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