Physiology 3120 Lecture Notes - Lecture 2: Electrochemical Gradient, Tandem Pore Domain Potassium Channel, Facilitated Diffusion

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Diffusion: simple diffusion, through cell membrane/lipid bilayer, through protein lined channel/pore. Polar molecules (ions and other water soluble molecules) cannot diffuse directly through the cell membrane due to the hydrophobic fatty acid region. They require a protein channel/pore (leak channel) Water shell must be removed by the specific channel so ion remains (cid:494)energetically stable(cid:495) + ions are going to have a water shell surrounding it. Factors affecting the rate of movement through protein leak channel: size, charge, electrochemical, pressure gradient, hydration energy (water shell)* * some of these factors act as *filters preventing one ion from passing through another ions channel this is not chemical specificity!!! The channel does not physically change shape as the molecules moving through the protein channel do not interact with the channel. Permeability: a measure of how easily an ion can cross a membrane (through pores/leak, depends upon the number and type of protein channel in the membrane.

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