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Physiology 3120 Lecture Notes - Goldman Equation, Nernst Equation, Axon Hillock

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indigoweasel955
26 Nov 2011
School
Western University
Department
Physiology
Course
Physiology 3120
Professor
Tom Stavraky

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Document Summary

Resting membrane potential: resting membrane potential, goldman equation ion in the equation. Membrane permeable to a variety of ions, so can"t use the nernst equation. Each ion affects the rmp depending on its permeability & concentration gradient. No valence in the equation because the charge is taken into account based on the position of the. Important ions (k, na, and cl) and their concentration gradients. Degree of importance of each ion at a particular time is proportional to membrane: rmp = -70mv (can vary from cell to cell) permeability. This potential maintains the concentration gradient of chloride. Some potassium will leak out because the rmp isn"t strong enough to counter the movement of potassium. Potassium moved back in using the na/k pump. Sodium (whose equilibrium potential is much higher than the rmp) theoretically should move down its gradient, but membrane is less permeable to sodium than potassium. Cells in the heart don"t have an rmp.

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Related Questions

Which motion of particles across a membrane requires energy?

A. From high concentration to low concentration

B. From low concentration to high concentration

C. With no concentration gradient

D. Through dynamic equilibrium

the driving force for diffusion is...?

a) the concentration gradient
b) the negative gradient of the chemical potential
c) the gas constant times the absolute temperature
d) the gravitational coefficient
e) gravitational acceleration

Hello,


Could you help? Will rate life saver:

Generate current/voltage plots forthefollowing situations:

a) A membrane contains onlychannelsthat are ideally selective for K+. Theconductanceof the membrane is 10 nS. There is no salt gradient.

b) A membrane contains onlychannelsthat are ideally selective for K+. Theconductanceof the membrane is 1 nS. There is a salt gradient.The“ground side” is 0.1 M KCl. The other side is 1 MKCl.

c) A membrane contains two setsofchannels. One set is ideally selective for K+ andtheother is ideally selective for Cl-. Theconductance ofthe K+ channels is 1 nS and that of theCl-channels is 5 nS. There is a saltgradient. The “ground side” is 0.1M KCl. The other side is 1 M KCl. Generate current/voltage plotsforeach set of channels separately and then plot combinedcurrent.