Physiology 3120 Lecture Notes - Pars Compacta, Basal Ganglia, Supplementary Motor Area

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indigoweasel955

26 Nov 2011

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Basal ganglia function of supplementary motor cortex (sma) first deduced using pet screens; measured blood flow, which is indicative of metabolic activity in neurons. Metabolic activity mostly due to epsps and ipsps, not aps. Simple finger flexion increased blood flow in somatosensory & motor cortex. Sequential finger flexions increased blood flow in somatosensory & motor cortex, and supplementary motor cortex. Think about sequential finger flexions increased blood flow in supplementary motor area only. Conclusion: supplementary motor area programs motor cortex when performing complex, sequential movements basal ganglia. 4 different loops; separate pathways through basal ganglia that end up back in the cortex classically associated with motor functions but there are other loops that are not motor areas: motor, oculomotor. 2. from the cerebral cortex from the substantia nigra pars compacta. The major neurotransmitters in the caudate/putamen are dopamine (excitatory or inhibitory), ach (for interneurons in the neostriatum), and glutamate.

Related Questions

Membrane Capacitance and Conductance. For cells having simplemorphological shapes, the
intracellular voltage is nearly uniform throughout the cell suchthat any change in the membrane
potential acts equally on all parts of the membrane. If wehyperpolarize the cell or chemically block
excitable ionic conductances, the membrane potential vm ispassively related to the incoming current i
by:
Cm
dvm
dt
+Gm (vm - El ) = i (1)
where Cm is the whole-cell membrane capacitance, Gm is thewhole-cell membrane conductance, and
El is the leak potential. Most biological membranes have acapacitance of about 1 ÂµF per square
centimeter of membrane area, which allows one estimate cell size bymeasuring capacitance.
a) One way to measure the capacitance is to inject a sinusoidalcurrent i = Ie j?t and to measure the
sinusoidal perturbation in the membrane potential vm = Ve j?t . Inthe frequency domain, both the
current I and the voltage V are complex-valued numbers. Derive aformula for the cell capacitance in
terms of I and V.
b) Another way to measure cell capacitance and conductance is touse a step current injection. In this
case, the current is suddenly increased to a constant i = Io andthe voltage responds with an exponential
form. Measurement of the voltage for a known current impulseprovides a means to estimate the
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current. Once you have this solution, how would you use the voltageand current measurements to
estimate the passive capacitance and conductance?

It is currently popular for automobiles to use 10% ethanol / 90%gasoline mixtures (âgasoholâ) as fuel. According to popularconsensus the main benefit of gasohol use is that it âreduces ourdependence upon foreign oil.â We test this assertion by making someelementary calculations. Our analysis will unrealistically ignoreengine maintenance issues associated with older automobiles (suchas gasket and seal hardening), added fuel consumption necessary toproduce grain used as a feedstock in ethanol production,incremental food price increases associated with a reduction ingrain stocks, and many other effects. Gasohol use typically reducesaverage fuel economy by approximately 15% and effectively leavesfuel prices unchanged. This article further debates the wisdom ofethanol use and may be of interest outside the problems:
http://harvardmagazine.com/2006/11/the-ethanol-illusion.html
These concerns and problems have been strongly influenced byconversations with Dr. H.J. Harmon, of the OSU physicsdepartment.

2. Consider a 14.2 mpg 1991 Ford F150 driven 761 miles. Calculatethe pure gasoline consumption of this truck when: a) usinggasoline, and b) when using gasohol (with its attendant economyreduction). Determine the total CO2 emissions for each fuelassuming all fuels produce 20 lbs of CO2 per gallon. Comment uponthe wisdom of using gasohol versus pure gasoline in this vehicle.

The figure shows three graphs, A, B, C, which collectively describe the motion of an object in one dimension. The horizontal axis of each graph is time (symbol t). The vertical axes of the graphs are different. For one graph the vertical axis is position (symbol x), for another, it is the velocity (symbol v), and for another, it is acceleration (symbol a). Where the axes across is the point of zero for both time and the quantity corresponding to the vertical axis. Part A: For which sequence of graphs is the vertical coordinate position, velocity, and acceleration, respectively? (e.g., If you think graph Y is position versus time, graph X is velocity versus time, and graph Z is acceleration versus time, then your answer is Y, X, Z.). Multiple choice: 1)C, A, B 2)A, C, B 3)C, B, A 4)B, C, A 5)B, A, C 6)A, B, C. Part (b) Which one of the following situations can be most accurately represented by the graph, consistent with your answer to part (a)? (1) A car driving in the negative x-direction suddenly shifts into reverse and, with tires spinning, slows to a momentary stop before beginning to move in the position x-direction. (2)A car driving in the position x-direction slams on its brakes and comes to rest. (3) A rock is dropped from the rest from the top of a tall building. Assume air drag can be neglected, in which case its speed increases by the same amount each second. Take upward to be the position x-direction. (4) A sprinter runs a 100-meter dash and she runs in the negative x-direction. Starting from rest, she has a constant acceleration for the first 50 meters, then a constant speed for the remaining 50. Multiple choices: 1)4, 2)3, 3)2, 4)1.

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Physiology 3120 Lecture Notes - Pars Compacta, Basal Ganglia, Supplementary Motor Area

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